Exosites expedite blood coagulation

Targeting exosites on blood coagulation proteases.

The high specificity of blood coagulation proteases has been attributed not only to residues surrounding the active site but also to other surface domains that are involved in recognizing and interacting with macromolecular substrates and inhibitors. Specific blood coagulation inhibitors obtained from exogenous sources such as blood sucking salivary glands and snake venoms have been identified....

Blood Coagulation

INTRODUCTION This section covers the means, as far as we now know them, by which components of the blood plasma produce an insoluble protein meshwork, or gel, at a site of blood-vessel damage. The plasma is normally completely fluid, containing all its proteins in soluble form. When the clotting system is activated at a site of blood-vessel damage, a series of proteolytic reactions is set going...

Stroke and blood coagulation.

Stroke and Blood Coagulation • A study of the coagulation parameters of 87 normal controls (ages 50 to 80) were compared with those of 33 patients with thrombotic stroke and 55 patients with diabetes mellitus of the same age distribution. There were no significant differences when tested for the influence of sex or age. Twenty-seven tests of clotting were done on each specimen, a total of 4,725...

Blood Coagulation and Thromboembolism

Editor: STANFORD WEssLu, M.D.

Changes in blood coagulation.